We have reached a tipping point. Societal and technological pressures are sparking a shift from animal testing to AI. This shift to AI will enable a completely new class of experimentation that brings the best aspects of basic early-stage experiments and premium late-stage animal tests and avoids the problems associated with each of them. Trained on massive amounts of high-quality data, AI could give us the cost efficiency and speed of early-stage experiments, the human and physiological relevance of late-stage experiments, and new, deeper insights into the mechanism of action to better contextualize the "why" that drives the results.